Patients with a genetic variant in the GNAO1 gene are rare, with an expected prevalence of 1: 100,000 – 1: 200,000. The clinical symptoms are impactful for patient and caregiver and are not limited to but vary from movement disorders, epileptic seizures, muscle weakness, and intellectual disability. Currently there are 107 different genetic variations of the GNAO1 gene described, and there is no clear correlation between the genotypes and the symptoms and the severity of the symptoms.

Despite some medications that might suppress the symptoms in certain patients, there is no cure for the GNAO1 as of today. Due to the combined efforts of researchers and patient advocacy groups around the world, disease specific insights are gathered. However, much more research is needed to obtain specific therapies, and even cure, for each individual patient.